The AIDS War May Not Be Falling Apart, but It IS Falling Behind
May 12, 2010
On Sunday the New York Times published four article on the battle against AIDS in Uganda which everyone should read who is interested in the AIDS epidemic, or in the effectiveness of US aid policy in general. The articles, all by the Times’ knowledgeable science reporter and long-time observer of the AIDS epidemic DonMcNeil, include:
- At Front Lines, AIDS War Is Falling Apart
- After Long Scientific Search, Still No Cure for AIDS
- As the Need Grows, the Money for AIDS Runs Far Short
- Cultural Attitudes and Rumors Are Lasting Obstacles to Safe Sex
These articles are a welcome blast of frank information about the difficulties faced by those with AIDS and those battling the epidemic on the front lines in Africa. However, the headline and the tone of the first and last of these articles is misleading. They give the impression that existing efforts, which have previously been successful, have stopped working. This characterization of the situation is largely false in the case of AIDS treatment and not even entirely true in the case of HIV prevention.
On the treatment front, I would not characterize the AIDS war as “falling apart” until I saw existing donors reneging on their implicit guarantee of a treatment entitlement to existing patients. As I have argued here, here and here, the US and other donors have implicitly established the first international entitlement by starting people on effective antiretroviral therapy. The US government does not like the term “entitlement,” preferring to use the term “mortgage” to refer to its implicit commitment to existing patients. But by any name, this commitment, to the extent that it is respected by the donors, locks in funding for AIDS treatment of existing patients. As long as funding increases, this constraint will not bind with respect to other uses for AIDS money. Unfortunately however, beginning with the reauthorization bill proposed by the Bush administration and passed by Congress before Obama took office, the rate at which total AIDS funding is increasing has slowed. The figure shows the slowdown in US funding since 2008 as it is projected on the PEPFAR website.

Figure 1. After growing at 25 % per year for 2004 – 2008, PEPFAR funding has grown at less than 5 % per year since 2008 and the mandated expenditure on AIDS treatment is constant since 2008. (Source: http://www.pepfar.gov/documents/organization/80161.pdf accessed April 25, 2010.)
When the total amount of PEPFAR support stops growing, US personnel and their partners in countries like Uganda must make hard decisions. As long as they respect the entitlement of existing AIDS patients, every other part of the AIDS budget will be squeezed. So the potentially available money to add new AIDS patients to the treatment rolls, as well as money for HIV prevention and care for orphans – and newly mandated efforts to strengthen domestic health provider training, etc. – will ALL be squeezed. But this doesn’t mean that AIDS treatment is falling apart. It’s the INCREASE in the number of patients on treatment that has been SLOWED – and even apparently frozen in some clinics.
Don McNeil’s article on treatment is misleading in another respect. It implies that the human tragedies it recounts that occur when people are turned away from treatment are only now appearing for the first time in Uganda. But for the last several years, despite the rapid acceleration of AIDS treatment access in Uganda, AIDS patients have been dying every year before they could find a treatment slot in a clinic. In fact for recent years less than a quarter of those estimated to be in desperate need of treatment actually received it each year. The latest data from UNAIDS estimates AIDS deaths to have been 77,000 in 2007. Increased treatment availability has reduced this number since 2007, but we estimate there to have been about 50,000 AIDS deaths in 2009. So the fact that people are dying of AIDS in Uganda is not new and should not be used to characterize the effort as “falling apart”.
The article on prevention is also misleading because it implies (1) that Uganda was previously a good example of how to do everything possible to prevent HIV and that (2) people have recently reverted back to the risky behavior of the past. On the first point, Uganda has definitely NOT made a serious effort with every possible promising HIV prevention intervention. It has not scaled up male circumcision or widely expanded couples counseling, two widely advocated promising interventions supported by evidence. Even more shocking, Uganda has never attempted to invent an African version of Thailand’s “100 % condom program” to assure that a condom is used on 100 % of the riskiest sexual encounters. The first step in such a program would be to establish a nationwide inventory of all the bars, truck stops, and other “hot spots” where people meet in search of romantic relationships. The research on the so-called PLACE method, invented by University of North Carolina researchers ten years ago and described here, is the first place for an African leader to look who really cares about HIV prevention. Why wasn’t this program rolled out ten years ago in Uganda? The reasons are many and include the US government’s obsession with the A (abstinence) and B (be-faithful) parts of the ABC prevention program. But part of the blame goes to those on the left of the political spectrum, so worried about the human rights of potentially stigmatized people with high risk behavior and the vulnerability of monogamous women that they insisted prevention efforts be diluted over the entire population – instead of focused on those contributing the most new infections as would have been possible using the PLACE method.
Has the behavior of Ugandans reverted? In one sense, yes, since HIV infection rates have risen among young women at some ante-natal clinics and self reported risky behavior has also risen. Perhaps this is due to complacency due to the widespread availability of free and effective AIDS treatment. However, despite my record of warning of such a possibility, there is no evidence that this “disinhibition” has yet occurred in Uganda. Instead it seems likely that part of the decline in prevalence and increase in risk behavior has been due to the deaths of those with the riskiest behavior, who were not lucky enough to get onto treatment. Their removal from the population would automatically reduce both prevalence and reported risk behavior. As a new cohort matures and becomes vulnerable to AIDS, it would not be surprising if the same percentage have unusually risky behavior as was the case a generation ago. So the rise in prevalence in risky behavior might be due to the arrival of a new younger cohort of vulnerable people and not to the same people who were practicing safe sex, changing their behavior and reverting to risky behavior, as the article implies.
Despite these misleading aspects of the NYT articles, the facts call out for a new way of thinking about the AIDS epidemic. Failure to sustain the promise of treatment was inevitable as long as the number of new infections remained high. The financial crisis has only slightly advanced that terrible day of reckoning. The international community has got itself into a terrible dilemma: treatment for AIDS is already consuming resources that could be used much more effectively to stop other killer diseases, like childhood diarrhea, and yet millions still lack access to treatment.
If we can’t treat everybody, what should we aim to do? Increasing AIDS funding, even if practical, will never be enough by itself to stem the epidemic. (For contrary views, see here and Gregg Gonsalves’ comment here. ) We must shift now to achieve an AIDS Transition: invest massively in prevention to reduce the number of new infections, so that, eventually, we will be able to attain high levels of treatment coverage AND have a declining number of people who are infected with HIV.
The idea of an AIDS transition is explained more fully in the first of a series of essays I will release next week.
7 Responses to “The AIDS War May Not Be Falling Apart, but It IS Falling Behind”
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May 14th, 2010 at 7:13 am
Mead-
I agree we need a massive investment in prevention.
Some of that is about resources and money, but some is about the approach we’ve taken to HIV prevention. You refer to some of the mistakes we’ve made in your piece, such as focusing too broadly in prevention efforts, when they need to be targeted at those at highest risk.
When I got to GMHC in 2000, I was asked to take on HIV prevention policy. As a good activist, I first started looking about what we knew about HIV prevention, what had worked to shift epidemics on the level of populations. What I found was scandalous. A lot of interventions around the world were focused on changing individual behavior, rather than seeking to make community-level changes or changing the policies that drive risk in the first place. It’s as if in trying to stem automobile deaths, or gun violence, we had made a massive investment in sitting Americans down one-by-one to explain why they should wear seat-belts, or how guns kill people. That is to say, we’ve never taken a public health approach to HIV prevention.
What gets trumpeted are a few examples of effective HIV prevention, like the 100% condom campaign, needle exchange, or circumcision, but no one ever says we are in a terrible state when it come to knowing how to prevent infections, that we have far too evidence-based tools at our disposal to make a big impact. If HIV prevention was treatment, we’d be back in the days of AZT alone. We need to become activists for better prevention, better prevention research, new ways of thinking. Simply talking as if it’s just about the money, let’s everyone off the hook for our failures in this field. It also will foster the continuation of the waste of millions of dollars on things that don’t work. Let’s get to work on HIV prevention, but let’s not pretend it’s a matter of simply more cash. And it’s not just about ideologues on the right or left who are creating problems in HIV prevention—it’s from within the field itself, from vested interests, fossilized thinking, a lack of self-criticism or analysis.
You talk like an economist—well, you are one! First we get infections down, then we can resume scale-up of treatment. I wish it could work that way. You know that knowing one’s status is a key part of HIV prevention—people who know they are HIV+ are less likely to transmit the virus. We also know that offering ART is a strong incentive for HIV testing. In Khayelitsha in Cape Town, ART increased testing rates, STI rates went down and there a plenty of other examples of ART bringing new people into HIV services, including those for HIV prevention. If we stop or slow treatment now, the incentive to know your status is greatly reduced. In addition, we know ART reduces viral load—despite the grandiose claims of some that we could stop the epidemic in five years with nationwide ART in some places, the truth is probably more modest but significant nonetheless: ART can blunt new transmissions if coverage is wide enough. And as Helen Epstein and others have remarked part of the best HIV prevention is mobilization, when communities get together to combat a danger in their midst together. ART has been a great community mobilizer across the globe, and not just for AIDS treatment, but a variety of HIV prevention work, from needle exchange and substitution therapy in the former Soviet States, to gender violence/rape prevention in South Africa. You and Bill Easterly like to talk about the separability of HIV treatment from HIV prevention, which flies in the face of what the people who actually work on service provision know—an integrated, comprehensive, community-based approach is best, working with communities to figure out what they need.
I think the separability of treatment and prevention is important for you and Bill because you simply—as you once said to me—think health care, ART provision is not a public good. As you told me: ART is like a loaf of bread, you consume it on your own. Well, first we know that ART has community level impact, so it is a public good as well. But the disagreement is more fundamental. You worry that AIDS care will gobble up foreign assistance if it is allowed to continue. For you, despite the fact that trillions materialize for bailouts of banks, countries, and car companies, you insist that foreign aid is fixed, by assuming this you accept it as a unchangeable reality and make the case to the rest of the Beltway crowd that it should be.
When you talk of ART as an entitlement, I apologize but all I can hear is the voice of Ronald Reagan, decrying “welfare queens” and people living off the tit of the public sector. You know historian Tony Judt wrote a book recently called Ill Fares the Land, it’s about the rise of free-market libertarian economics over the past 30 years, the rejection by policy makers of a mid- 20th century consensus on social welfare and social democracy. Part of your analysis and Bill’s is part of what Judt talks about—a rejection of the role of the state, or at least a substantial downgrading of the state’s role in social welfare. Nations, and the community of nations and the people who live in them should look to democracy and the market for their futures, not to their governments for the sons of Milton Friedman.
As my mother says: what do you think? Money grows on trees? No, mom, I don’t. However back in the 1990s, we had a battle called the “disease wars” around NIH funding—the refrain was similar to today’s: AIDS gets too much money compared to other bigger killers. We made the same case we make today-the investment in AIDS, in prevention AND treatment, and research is vital. But it was Christopher Reeve who came to the rescue, Superman that he was. His foundation joined with us to say, we need to work together to lift all boats, and boost the NIH budget, let’s double it. Guess what: it worked: we got the NIH budget doubled in the 1990s. Sometimes money does grown on trees.
Yes, there are limits, but if we could get all OECD countries to put up 0.7% of their GDP, we’d be making far fewer Sophie’s choices. Governments have made commitments to these sums already we’re not asking for anything new. There will always be trade-offs, we triage now. But if we treat all of this a zero-sum game for eternity, we are doomed. We have too much to do in HIV/AIDS, in TB, maternal and child health, health systems, sanitation, education, housing, the environment to settle for this. In the end this is about the planet we want to live on, the kind of world we want it to be.
You and Bill tell leaders what they want to hear: go back to the old ways before these uppity activists started calling out governments on health care. You know several of my colleagues got thrown out of Tanzania last week for trying to simply hand over a memo to leaders assembled at the African Economic Forum in Dar es Salaam about the need for African leaders to invest in health, not in self-enrichment, Mercedes-Benzes and fighter jets. By and large these were young people, speaking up, risking arrest, young Africans saying the world can be different. When the history books are written, I want to be on that page with them, not among the purveyors of the status quo, who have always said, wait, we can’t do this, it will ruin the economy (e.g. FDR’s critics during the New Deal, LBJs during the Great Society), we can afford it, be patient, we’ll get to it some day. You will say that oh, I am just a dreamer. Well, no actually. Ill does far the land. The sickness is among those who are defenders of 30 years of economic ruthlessness disguised as sound policy. You say we can’t afford ART. I say we cannot not afford it.
May 14th, 2010 at 2:37 pm
Actually, the headline is correct. It is a mistake to think the funding slowdown only limits the program’s ability to meet needs of new patients. You have to ask about the quality of existing care. There is evidence that some PEPFAR and government implementers are filling partial drug prescriptions because of uncertain or insufficient funding. We are seeing an impact on the quality of existing treatment, which could affect adherence. In his House testimony Peter Mugyenyi warned about patients beginning to share pills. These and other concerns are discussed in the memo located here:
http://writingrights.org/2010/.....-globally/
May 17th, 2010 at 10:34 pm
Surely treating people and extending lives are only part of the equation—and that a balanced response where prevention takes on greater importance is vital.
However, unfortunately, failed policies and the absence of sustained leadership are beginning to reverse gains, constraining service providers to once again make painful decisions about “who lives and who dies” as one NY Times letter writer describes:
http://www.nytimes.com/2010/05.....5aids.html
As a global community, we should do much better.
May 19th, 2010 at 9:35 am
Thanks to Gregg for detailing the synergies between prevention and treatment and to David for linking us to the manifesto announcing a campaign by the South Africa-based Centre for Law and Social Justice to “reverse” current US policy. And Jirair has helpfully linked us to the Letters posted at the NYT.
Gregg, I hope you will read and comment on an essay I have just posted which proposes a new paradigm, which I call the “AIDS transition”. Adoption of this paradigm by all of us who struggle against AIDS would link prevention and treatment together with much stronger bonds of policy than has ever before been attempted. And, as I argue at the end of the essay, this linkage would provide our fiscal watchdogs with a justification for allowing additional fiscal space for AIDS treatment. The essay is posted here: http://www.cgdev.org/content/p.....l/1424143/
June 2nd, 2010 at 12:39 pm
Hi, Mead.
I agree that we can’t simply focus on AIDS treatment and not address the expansion of the queues of those waiting by failing on HIV prevention. I don’t think anyone in their right mind could disagree!
Sadly, my sense is that there HAS been an investment in HIV prevention and as I mentioned above, but it has been spectacularly unsuccessful. Does this mean we give up? Hell, no.
But we need to take on the prevention mafia and clean house (sorry for the mixed metaphors)–let’s analyze where prevention money has gone to date, what we’ve got for our investment, bring together experts (from AIDS and non-AIDS disease prevention fields) to assess what “combo” prevention regimens might work and where and then go get the money to fund it. This is what we’ve done as activists in almost all areas of HIV/AIDS programming–but somehow prevention has escaped any rigorous critical analysis, except probably among those working on these issues in terms of intravenous drug use. I say this as part of the Global HIV/AIDS Prevention Working Group, sponsored by Gates and Kaiser: I haven’t seen us reflect on our failures and do any real hard thinking in the several years I’ve been part of this group. I can tell you to raise these issue will get you in trouble–there is strong resistance to change in the HIV prevention field.
One thing I would like someone to do is to calculate the prevention benefit of ART–not as part of grandiose schemes of full coverage of ART, but in real terms. What do we get for 4 million people on treatment now in terms of infections averted? And yes, we need to ensure better adherence, which to me means engaging people on ART through “treatment literacy”. However, there is little appreciation among clinical types for this kind of active health education.
Finally, I hope that in the zeal towards horizontal programming, people realize that health systems need breadth and focus–pendulum swings too far in either direction aren’t productive…
On a last note, no one thought ART would become an entitlement 10 years ago. I’d rather call it a right–I know it won’t sit well with you but I do think the poor have a right, an entitlement to health. We can only hope for the expansion of these rights and entitlements to take on more areas of health and development in the future, which means we have to stop thinking of things as a zero-sum game. We know that money “appears” out of thin air when it is needed for rescues of Wall Street firms, wars and other priorities. We can afford to do these things, in fact, don’t really blink an eye at these vast sums, but somehow get caught up with penny-pinching with health and development. We broke through a threshold in 2000 in the scale-up of ART-we have to keep pushing forward, expanding the scope of health care for the poor. Some will say it’s unsustainable, but how is allowing inequities to expand, disease to spread, sustainable in the long-run?
June 3rd, 2010 at 4:03 am
In many different ways, the devastation of AIDS among individuals and families ultimately affects a country’s overall economic performance. The loss of experienced workers and skilled professionals saps production in key sectors. More insidiously, AIDS can erode the people’s morale, weakening their confidence in the future, further harming productivity and undermining their willingness to save and invest.
Foreign investors also are becoming increasingly concerned about the implications of the HIV/AIDS epidemic, at a time when Africa is seeking to attract more international investment. For foreign investors uncertainty means sell rather than hold much less invest more money.
According to some estimates, annual per capita economic growth in Africa is 0.7 per cent less because of the cumulative impact of AIDS. Such estimates are seriously unreliable, however. There is a paucity of accurate data both on AIDS itself — precisely who is infected, in which economic sectors — and on how the illness actually affects different economic activities. Nor can the impact of AIDS be easily separated from other factors.AIDS is part of a whole. It will have a macroeconomic impact.But you cannot disimpact AIDS from labour legislation, for example.
Nevertheless, numerous studies agree that AIDS can seriously slow down economic growth, to varying degrees. UNAIDS has estimated that when HIV prevalence rates rise to more than 20 per cent, gross domestic product (GDP) in those countries can be lowered by as much as 2 per cent a year. In South Africa, the investment bank ING Barings has projected that HIV/AIDS could drag down GDP by 0.3-0.4 per cent a year. Another study has indicated that by the end of the decade, AIDS could have knocked South Africa’s GDP by 17 per cent, or $22 bn.
The UN Development Programme (UNDP), in its Botswana Human Development reports, cites government studies that HIV/AIDS will result in GDP being between 24 per cent and 38 per cent lower by 2021. Studies have indicated that 2 per cent of the workforce in that country is showing clinical signs of AIDS. Over 25 years, GDP could be 40 per cent lower than without HIV/AIDS.There will be an increased cost of skills. There is a need to put in place practices to maintain productivity and prevent a skills-related bottleneck.
February 17th, 2011 at 2:17 pm
I can’t say that I know as much about this subject as the other commentators here, however I would say that the rate of funding for AIDS is likely to diminish whilst the world’s economy is under pressure, which has been the case since around 2008. Also, in reference to something Gregg said “What I found was scandalous” – I think that governments in the worst affected regions of the globe are simply overwhelmed by agreeing to international policies (official or unofficial), that conflict with other efforts in either an accidental or deliberate way. Please read between the lines here as I do not want to make it too obvious.